Sugar acids and derivatives
Medchemexpress LLC JBI-589 | 2308504-22-3 | 99.8% | 481.56 g·mol⁻¹ | C29H28FN5O | 10 MG
JBI-589 is a non-covalent, isoform-selective inhibitor of peptidylarginine deiminase 4 (PAD4) with oral bioavailability, developed for preclinical cancer and immunology research. It reduces CXCR2 expression, blocks neutrophil chemotaxis, and has shown activity in reducing primary tumor growth and metastasis in experimental studies.
- Selective PAD4 inhibition with demonstrated activity in cellular assays.
- Orally bioavailable small molecule suitable for in vivo studies.
- High chemical purity for research use.
- Soluble in DMSO at high concentrations (requires sonication).
- Stable when stored under recommended powder and solvent conditions.
Medchemexpress LLC Heparin calcium | 37270-89-6 | MFCD00131296 | ≥98.0% | 3600-5000 | Not specified (heterogeneous polysaccharide; no single chemical formula) | 25 MG
Heparin calcium (MW 3600-5000) is a low-molecular-weight heparin anticoagulant supplied for research use. It binds antithrombin III to inactivate thrombin and other activated clotting factors, preventing fibrin formation. The material is provided as a white to off-white solid with good aqueous solubility and is intended for laboratory assays involving anticoagulation or coagulation pathway studies.
- Intended for research use only.
- Anticoagulant that binds antithrombin III to inhibit coagulation.
- Molecular weight range 3600-5000.
- Supplied as a white to off-white solid.
- Soluble in water (≈200 mg/mL with ultrasonication).
- Store sealed and dry at 4 °C; in solution, store at -20 °C to -80 °C per guidelines.
- Typical purity ≥98% (batch-specific certificate of analysis available).
- Available in small laboratory package sizes (example: 25 mg).
Apexbio Technology LLC HMP Linker 68858-21-9 100g
HMP Linker is an acid-sensitive linker used in solid-phase peptide synthesis (SPPS) It is designed to facilitate the covalent attachment of peptide carboxy-terminal residues to solid-phase resin supports and enables controlled cleavage of synthesized peptides under mildly acidic conditions thereby preserving the structural integrity of sensitive functional groups and peptide termini HMP Linker acts primarily by hydrolyzing upon acid catalysis which allows the intact release of peptides from resin supports Based on these properties HMP Linker holds research potential in peptide therapeutics synthesis and studies requiring mild peptide cleavage conditions
![eMolecules 383132-63-6 | 6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502184941.JPG-250.jpg)
eMolecules 383132-63-6 | 6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913
6-(Methylsulfonyl)-1h-indole-2-carboxylic acid | Combi-Blocks | 383132-63-6 | MFCD02664464 | 239.250 | C10H9NO4S | 96.000 | CS(=O)(=O)c1ccc2cc([nH]c2c1)C(O)=O | 1g | 401039913
Medchemexpress LLC Integrin alpha 8 bet 500ug
Integrin -8/ -1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC FN1 SPP1 TGFB1 TGFB3 and VTN It plays a role in multiple cellular interactions critical for organogenesis including NPNT as a functional ligand in nephrogenesis Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein expressed by HEK293 with C-10 His C-Flag labeled tag Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) has molecular weight of 85-140 kDa
BIOHIPPO T-bet-TAR-Puro LV
T-bet-TAR-Puro is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Medchemexpress LLC 4-methylumbelliferyl α-L-iduronide | 66966-09-4 | MFCD00135894 | ≥99.0% | 352.29 g/mol | C16H16O9 | 500 UG
4-Methylumbelliferyl α-L-iduronide is a fluorogenic reagent used as a sensitive substrate for α-L-iduronidase and related lysosomal enzyme assays. Enzymatic hydrolysis releases 4-methylumbelliferone, permitting fluorescence-based detection and quantitation in biochemical and cell-based assays.
- Fluorogenic substrate for α-L-iduronidase assays.
- Enables sensitive fluorescence detection and quantitation.
- High purity (≥99.0%) suitable for biochemical applications.
- Available in small research quantities (for example, 500 μg) for assay development.
- Stable solid form for convenient storage and handling.
![Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy β D galactopyranoside [4 Methylumbelliferyl N acetyl β D galactosaminide], 100 Mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660138.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl 2 acetamido 2 deoxy β D galactopyranoside [4 Methylumbelliferyl N acetyl β D galactosaminide], 100 Mg
Methylumbelliferyl β-D-Galactosaminide (100mg) is a high-purity reagent used in biochemical assays for the detection of galactosaminidase activity. This substrate, upon hydrolysis by the enzyme, produces a fluorescent product, which is measured for enzyme activity quantification. It is widely used in laboratories studying enzyme kinetics, carbohydrate metabolism, and related research fields. The 100mg product provides ample quantity for high-throughput screening and other analytical applications requiring precise measurement of enzyme activity. It is particularly useful in pharmaceutical and clinical research for screening enzymes or substrates involved in metabolic disorders and drug development.
Alkali Scientific LB Agar, Low Salt Formula, Granulated (Lennox Agar), 500 G
LB Agar, Low Salt Formula (Lennox Agar) in a 500g granulated form is a medium designed to grow bacteria while maintaining controlled osmotic conditions. This formula, which contains a reduced amount of salts, is ideal for research applications that require a lower ionic strength. It supports the growth of a broad spectrum of bacterial species, including laboratory strains like E. coli, and is especially useful in genetic research and molecular biology applications. The granulated form is easy to prepare and ensures quick dissolution in water, making it convenient for researchers who require high-quality bacterial growth media with reduced salt content for precise experiments and assays.